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Patients with certain genetic profiles may experience more pronounced gastrointestinal symptoms during treatment initiation, which could indirectly contribute to chest-wall discomfort

Tirzepatide dosing protocols typically start at low levels and increase gradually over months

The impact on insured groups is likely to be somewhat lower, and it may be too early to make material adjustments to insured trend assumptions, but the efficacy of AOMs to date increases confidence in future mortality and morbidity improvements

November 2025: FDA approved expanded Zepbound (tirzepatide) indication for moderate-to-severe obstructive sleep apnea in adults with obesity, following SURMOUNT-OSA trial data showing 62.8% reduction in apnea-hypopnea index the first drug approval for sleep apnea treatment

to 9 p.m EST, for everyone else

Given the complexity of eating disorders, multidisciplinary care is ideal, involving collaboration between primary care providers, psychiatrists or psychologists specializing in eating disorders, and registered dietitians