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The biology of mammalian multi-copper ferroxidases

The detoxification against H 2 O 2 in mitochondria occurs mainly through the GSH redox system, including the glutathione peroxidases (Gpxs) and GSH reductases, as well as the presence of peroxiredoxins (Prxs

Current CVD research reveals a critical knowledge gap: although preclinical studies robustly demonstrate that ferroptosis inhibition attenuates tissue injury, the molecular pathways governing its activation are highly context dependent, and its definitive contribution to human disease progression remains incompletely defined

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