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There is a deviation from normal mechanisms, with overexpression of IL-1, TNF-, and Monocyte Chemoattractant Proteins (MCP-1) in serum ( Tissue hypoxia Hypoxia, or a deficiency in oxygen supply, can significantly affect various cellular processes, including the plasticity of circulating monocytes involved in wound healing

In addition, the brain is susceptible to oxidative stress because its high in fat, which can oxidize or go rancid. The brain is also high in iron and zinc, which can further fuel oxidative stress

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10 Without treatment, progression timelines vary: This is why root-cause healing rather than surface-level treatment is so important for preventing unpredictable flares over time

J.RonaiZ.1999Regulation of JNK signaling by GSTp.18132134 2

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