Interestingly, Fab 3F52 blocked the BMS21-induced response with potency in the low nanomolar range, similar to the inhibition of native GLP-1
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Conversely, blocking IL-22 production has been shown to worsen the condition of colitis [183, 184]
Psychiatry 133 , 111029 (2024)
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This class of MCTs contains two members, namely SMCT1 (SLC5A8) and SMCT2 (SLC5A12), that mediate cellular uptake of monocarboxylates in a sodium (Na + )-coupled manner (Srivastava et al., 2019)