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Cultured cells have limited lifespans, restricting long-term investigations into processes like amyloid plaque accumulation, tau tangle formation, and progressive neuronal degeneration (Rodriguez-Jimenez et al., 2023)

5H, I), implying that VRK2 conferred the resistance of ferroptosis induced by ROS through facilitating the trafficking of SLC7A11

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(8) Meiotic maturation measurements included the rates of GVBD and first polar body extrusion (PBE)

Ethics declarations Ethics approval and consent to participate This study was conducted in accordance with the principles of ethical research practice: Animal Experimentation Ethics Committee of Zhejiang Eyong Pharmaceutical Research and Development Center, SYXK (Zhe) 2021-0033

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