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Exploratory endpoints include changes in resting-state fMRI measures from baseline to week 24 and their associations with smoking- and metabolic-related outcomes

Oxygen uptake and cardiac performance in obese and normal subjects during exercise

Thyroid function changes Some studies and case reports suggest GLP-1s may lower thyroid stimulating hormone (TSH) levels, possibly through direct effects on the hypothalamic-pituitary-thyroid (HPA) axis, and delayed gastric emptying (affecting medication absorption)

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Patient assistance programs can significantly reduce medication costs for eligible individuals