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Functional enrichment analysis indicated these intersecting genes are primarily involved in biological processes including oxidative stress responses, smooth muscle cell proliferation, and reactive oxygen species (ROS) responses, closely matching RA pathological features such as excessive inflammatory factor release and oxidative stress injury ( We further applied three classical machine learning algorithms (LASSO, RFE-RF, and SVM) to cross-validate and identify two core genes, GPX3 and MYC, which were subsequently validated using an MLP model
doi: 10.1242/jcs.248864 157 OlonaAMukhopadhyaySHateleyCMartinezFOGordonSBehmoarasJ
FIGURE 6 Apoptosis is a caspase-dependent form of programmed cell death that proceeds through two major pathways: the extrinsic Fas cell surface death receptor/Fas ligand (Fas/FasL) axis and the intrinsic mitochondrial pathway (Rebane et al., 2012)
