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Technically the two modeled proteins are GPX4 U46C-R152H and GPX4 U46C

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When weekly dose exposure is equivalent, outcomes are comparable

How It Is Studied Pharmacological characterization of sema at the GLP-1 receptor uses cAMP accumulation assays in GLP-1R-expressing HEK293 cells, radioligand competition binding with [125I]-GLP-1 or [3H]-exendin-4, and beta-arrestin recruitment BRET assays to determine binding affinity, efficacy, and biased agonism profiles

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