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Subsequent clinical double-blind controlled trials indicated that multi-dose flavonoid regimens (200800 mg daily) were safe, well-tolerated, and without significant accumulation, supporting the potential of flavonoid-based supplements in PD management (Pang et al., 2016)

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For women over 50 with already-thinning skin and a compromised moisture barrier from hormonal changes, this distinction is not trivial

In these cases, evidence suggests that a higher intake may be necessary to see visible changes

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