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CR-fed females showed upregulation of pathways including Lysine degradation, and Valine, leucine, and isoleucine degradation. Interestingly, DL-fed females had no significantly upregulated pathways, and indeed CR-fed females had upregulation of Valine, leucine, and isoleucine biosynthesis, while DL-fed females had downregulation of this same pathway

These studies lay a foundation for developing dual IGF-IR/InsR inhibitors such as BMS-754807 and linsitinib (OSI-906)

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Clin Exp Hypertens 2008