3.2.1 Effect of appendectomy on CRC According to the results of IVW, appendectomy did not increase risk of CC: Colon cancer(MRC-IEU)(OR:1.009, 95%CI:0.984-1.035, P=0.494), Colon cancer(Neale lab)(OR:1.016, 95%CI:0.993-1.040, P=0.174)
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Assessment data were collected at the next possible in-person visit
Additionally, promising effects have been observed in a phase 2 clinical trial of the CCR2/5 antagonist cenicriviroc [200], which suppresses monocyte recruitment to the liver and has demonstrated a reduction of liver fibrosis in rodents [201,202,203,204,205]
Confirmatory secondary outcomes included the percentage of patients who achieved a 10% or greater reduction in weight by week 104, a 15% or greater reduction in weight by week 104, and change from baseline to week 104 in waist circumference, systolic blood pressure, and SF-36 (physical functioning)
Zhao J, Harada N, Kurihara H, Nakagata N, Okajima K
