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When present, classic findings include: Unilateral leg swelling (edema, increased limb circumference) Pain or tenderness along the course of the deep vein, often exacerbated by walking or dorsiflexion (Homans sign low specificity, rarely documented) Erythema or skin warmth over the affected limb Skin discoloration cyanosis (phlegmasia cerulea dolens in massive DVT) or pallor/blanching (phlegmasia alba dolens) Dilated superficial veins (collateral vessel prominence) Pitting edema distal to obstruction Upper extremity DVT may present with arm swelling, cyanosis, heaviness, or Paget-Schroetter syndrome (effort thrombosis in athletes/manual workers following strenuous use)

One 2023 study in Circulation even found that clearing senescent cells, including with FOXO4-DRI, worsened pulmonary hypertension in rodents

doi:10.1016/j.powtec.2015.03.045 Dabhi B, Chavda K, Jindani A, et al (2013) Stability indicating ultra performance liquid chromatographic method for assay and content uniformity study of amisulpride in pharmaceutical dosage form

This is particularly useful for people who have difficulty absorbing B12 through food or oral supplements

At each timepoint, visually guided optomotor responses and retinal anatomy were assessed

Mechanisms of fibrosis: Therapeutic translation for fibrotic disease