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Fatty acid acylation enables albumin binding to extend circulation half-life
Abbreviations AMPK: 5'AMP-activated protein kinase AP: Acute pancreatitis ARE: Antioxidant response element ATRA: All-trans retinoic acid BRB: Berberine CP: Chronic pancreatitis DAMPs: Damage-associated molecular HO-1: Heme oxygenase 1 IFN: Interferon IL: Interleukin Keap1/Nrf2: Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 LPS: Lipopolysaccharide MAPK: Mitogen-activated protein kinase NFB: Nuclear factor kappa-b NLRP3: NOD-like receptor family pyrin domain containing 3 NQO1: NAD(P)H quinone dehydrogenase 1 OS: Oxidative stress PDAC: Pancreatic ductal adenocarcinoma polyI:C: Polyinosinic:polycytidylic acid RA: Retinoic acid RAR: Retinoic acid receptor RIP3: Receptor interacting protein 3 ROS: Reactive oxygen species SOD: Superoxide dismutase TAK-242: Transforming growth factor -activated kinases VA: Vitamin A References Abdelzaher WY et al (2021) Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis
doi:10.1016/j.eclinm.2024.102689 Truveta
This is because it stimulates melanin production, which darkens the skin but does not provide effective UV protection
14 - 19 Likewise, commonly thought to have essential wound healing potential, 30 the standard peptidergic growth factors for the wound healing concept confront with an alike problem in practical realization of the high theoretical potential
doi: 10.1002/ptr.2535
