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The SARS-CoV-2 infection initiates complex human host-pathogen interactions and alters mitochondrial function with significant disruption of glycolysis/TCA cycle (Warburg effect), affecting several metabolic pathways of amino acid (AA), fatty acid (FA), nucleotide, and antioxidant synthesis 139,140

Furthermore, inhibition of complex I activity can lead to an increased production of reactive oxygen species (ROS) [143], which could amplify cellular damage

Cagrelinide is a a cyclic peptide composed of 38 amino acids, with a sequence containing 38 amino acids and a pair of disulfide bonds

M., Auerbach, P

Bates, D