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At the conclusion of this trial, the liraglutide-treated group exhibited a significant reduction in HbA1c level by about 1.12% compared to the exenatide group, which had 0.79% reduction

Therefore, these GLP-1 RA treatments may be cost-effective alternatives for people with T2D for whom an SGLT2i therapy is considered

Why It Matters: Food in the digestive system competes for absorption, reduces bioavailability, and may bind to the compound, limiting effectiveness

Triple agonists add glucagon receptor activation, which: Increases resting energy expenditure by 8% to 12% (Jall et al., Diabetes Care 2024) Promotes hepatic fat oxidation and reduces steatosis May offset some of the lean mass loss seen with GLP-1 monotherapy (early signal, not yet confirmed in long-term trials) The weight loss ceiling for retatrutide appears to be 24% to 26% based on phase 3 data, though long-term real-world outcomes are not yet available