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Schroder, K., Zhou, R

Semaglutide activates GLP-1 receptors throughout the body, producing effects in the pancreas (enhanced glucose-dependent insulin secretion, suppressed glucagon release), brain (appetite suppression via hypothalamic satiety centers), gastrointestinal tract (slowed gastric emptying), and cardiovascular system (potential cardioprotective effects)

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Sanofis results from the Phase 2 study showed that efdoralprin alfa, a recombinant human alpha-1 antitrypsin (AAT)-Fc fusion protein therapy met all primary and key secondary endpoints when dosed every 3 weeks or 4 weeks in adults with alpha-1 antitrypsin deficiency (AATD) emphysema (a rare disease), offering a more convenient and potentially more effective option

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