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Nevertheless, if drugs inhibit ThDP-dependent enzymes, as, e.g., omeprazole does (157), direct exposure of the gastrointestinal system to oral drugs may increase its vulnerability compared to other tissues

As encouraged by Llins et al (76), Despite significant investment in processes to find all the possible polymorphs of active pharmaceutical ingredients (APIs), new polymorphs can suddenly appear without warning

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Neoplasia 9 , 222235 (2007)

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