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The main additional risk when combining with glipizide is low blood sugar

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Taking it slow under your doctor's guidance lets your body adapt, helps you both see how the medication works for you, and allows for any needed adjustments." If you experience significant side effects when you move up a dose, your doctor has options: Delay the dose increase: Your doctor may keep you on a lower dose for an extra four weeks to give your body more time to adjust before trying to move up again

Toxicol Pathol 17, 64250