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Consequently, suppression of IL-1 via GLP-1 receptor mediation, particularly through the pathway involving PKC-mediated inhibition of the nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing-3 (NLRP3) inflammasome, can further contribute to reducing the formation of a profibrotic environment

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While the placebo group experienced a reduction in plasma carnitine levels during the course of the study, the women receiving the carnitine supplement did not