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It might feel good initially, but it can also intensify any existing discomfort

What exists is preclinical, and it is thin: Rodent and in-vitro work described procognitive and synaptogenic effects (McCoy 2013, PMID 23055539 now under an Expression of Concern

Doctors may also consider how a patients response has changed over time

Aquaporin and blood brain barrier

Effects on biological aging markers and cellular health emerge over months and may continue improving during off-cycle periods as activated cellular processes continue operating

PSEN1 mutant iPSC-derived model reveals severe astrocyte pathology in Alzheimers disease