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Cermak SA, Duker LI, Williams ME, Dawson ME, Lane CJ, Polido JC

While the GH-based peptides work on the fat burning side of the equation, semaglutide works on the energy intake side by mimicking GLP-1, a hormone that controls appetite, insulin secretion, and gastric emptying

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While pharmaceutical therapies dominate current clinical practice, nano-empowered combination therapy offers promising solutions to overcome the limitations of monotherapy and associated side effects

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The underlying mechanism involves A oligomers inducing neuronal insulin resistance through the activation of TNF- and stress kinases such as JNK, IKK, and PKR (Mai et al