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considered electron microscopy characteristics of the urothelium and demonstrated defects in umbrella cells (denudation, increased pleomorphism, and decreased microplicae of the cell membrane) in patients with IC/BPS (diagnosed using ESSIC 2008 criteria) compared with controls

The events cited reflect experience gained under closely monitored conditions of clinical trials in a highly selected patient population

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Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2