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Reduced CII activity has consequences for central carbon metabolism because CII is involved in the conversion of succinate to fumarate within the TCA cycle 73

He has multiple issues with allergies/asthma/detox etc

Drug-induced malabsorption: Long-term medications like metformin or proton-pump inhibitors can reduce B12 absorption

therefore, low serum B 12 levels may be more prevalent among vegetarians, and especially vegans

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[7] In addition, oral contraceptives have been noted to lower serum B levels, though this effect is usually clinically insignificant