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Unsaturated fatty acids represent a primary target for the protonated O 2

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Firstly, metformin inhibits mitochondrial complex 1, and this in turn may reduce the production of reactive oxygen species [85, 86], thought to be involved in cellular damage and mitochondrial dysfunction

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Taking spironolactone in combination with other medications for hypertension and heart failure can reduce the risk of strokes and heart attacks

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