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Primary hallmarks of cellular senescence include cell-cycle arrest, resistance to cell death, and senescence-associated secretory phenotype (SASP) ( Figure 3B )

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They are also examining various mouse models of inflammation, including heart disease, atherosclerosis, and liver and kidney inflammation, to determine whether the beneficial effects of GLP-1 in each case are indeed mediated through the brain

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SepandarFDaneshpazhoohMDjalaliMMohammadiHYaghubiEFakhriZet al

The finding that stopping GLP-1 drugs can undo years of heart protection is resonating