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Upon afamelanotide binding with the MC 1 R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment) over pheomelanin (red/yellow pigment)

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l-Carnitine is a trimethylated amino acid that is structurally similar to choline and is needed as a cofactor to convert long-chain free fatty acids to acylcarnitine and transfer them to the mitochondrial matrix