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Case reports and reviews describe: Rapid darkening of moles, eruptive nevi and cases of melanoma temporally associated with Melanotan II use, often in the setting of intense UV exposure

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This selective degradation of damaged mitochondria is mediated by key regulatory proteins, including PTEN-induced putative kinase 1, BCL2 interacting protein 3, and FUN14 domain-containing protein 1, and is essential for maintaining mitochondrial quality control (Quirs et al., 2016

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