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Standard qualification criteria include: BMI 30 kg/m (obesity) regardless of comorbidities BMI 27 kg/m (overweight) with at least one weight-related condition such as type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease Age 18 years or older (Wegovy and Saxenda are also approved for adolescents aged 12 and above

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A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

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