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These are small steps that preserve potency across an entire multi-week titration cycle

MC1R and MC4R are thought to be the most relevant

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in particular, it reduces hepatic glucose production through suppression of gluconeogenesis and increased oxidation of fatty acids, inhibits lipolysis and subsequent FFA release from the adipose tissue, enhances glucose uptake and storage from the muscle, and reduces intestinal glucose absorption [32]

Thyroid hormone over-replacement is associated with increased risks of atrial fibrillation or flutter (AF/Aflutter) and stroke, especially in older individuals with T2D and obesitypopulations already at elevated cardiovascular risk [30,31,32,33,34,35]

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