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This function is supported by findings that GGT deficiency, either clinical or experimental (GGT knockout mice), is associated with glutathionuria because of the absence of GGT activity on the apical surface of the cells in the proximal tubules of the kidneys and reduced content of cysteine in plasma and cells [13]

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Importantly, the study used a statistical approach called a modified treatment-regimen estimand, which allowed for valid comparisons between groups by accounting for participants who discontinued the trial drug, changed therapy, or dropped out

doi:10.1007/978-3-319-98788-0_3 Yuan L, Kaplowitz N

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