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Jazayeri et al., 2017)

DSIP crosses the blood-brain barrier freely an unusual property for a peptide of its size via a non-competitive, non-saturable passive mechanism whose physicochemical determinants (lipophilicity, charge, molecular weight, and protein-binding) are now well characterised

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Key advantages include optimizing nanorobot design, predicting trans-biological barrier behavior, and dynamically adjusting delivery parameters via real-time feedback loops (Rai et al., 2023)

Samples were incubated for 45 min at 37 C on a shaking heat block, centrifuged at 700 g 4 C for 30 s, and then placed on ice for immediate LCMS analysis