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Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus

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Each increment in BMI of 5 kg/m 2 greater than 22,525,0 kg/m 2 corresponds to a rise in overall mortality of 30% ( Obesity pathophysiology is multifactorial and involves social, psychological and behavioral factors, genetic and metabolic predisposition ( Obesity is directly related to the development of cardiometabolic disease (arterial hypertension, coronaric syndrome or heart failure ( Its also associated, in addition, with obstructive sleep apnea (OSAS), non-alcoholic fatty liver disease (NAFLD)/metabolic-associated fatty liver disease (MAFLD), osteoarthritis, gastro-esophageal reflux disease, malignancies (gastrointestinal, liver, breast, and endometrial cancer), and mental health issues, especially in young people

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