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"Network analysis of metabolic enzyme evolution in Escherichia coli"

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Abbreviations AA Alopecia Areata NAC N -acetylcysteine System XC Cystineglutamate transporter exchange transport system EAAT3 Excitatory amino acid transporter 3 ASCT Alanineserinecysteine transporter GSH Glutathione Hcy Homocysteine CBS Cystathionine--synthase CSE Cystathionine--lyase GGT -Glutamyl transpeptidase ROS Reactive oxygen species MT Metallothionein Nrf2 Nuclear factor erythroid 2-related factor 2 PTEN Phosphate and tensin homolog deleted on chromosome 10 PTP Protein tyrosine phosphatase CoA Genome-wide association studies CoA Coenzyme A TCA Tricarboxylic acid TRP-1 Tyrosinase-related protein 1 TRP-2 Tyrosinase-related protein 2 GPX4 GSH peroxidase 4 mTORC1 Mechanistic target of rapamycin complex 1 Rag Recombination activating gene 4EBPs Eukaryotic initiation factor 4E-binding proteins -glucys Amino-acid transporter solute carrier family 7 member 11(SLC7A11) -glutamatecysteine INF- Interferon HHcy Hyperhomocysteinemia CRH Corticotropinreleasing hormone Author contributions Wen Xu, Xie Bo, Dongfan Wei and Xiuzu Song drafted the manuscript and prepared the figures