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The temperature difference between refrigerated solution and body tissue creates a localized reaction that manifests as stinging or burning

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We find that the hydrogel can also alleviate the inflammatory reaction and regulate oxidative stress in situ to establish a microenvironment conducive to healing

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However, a definitive antibody-mediated mechanism of enhancement has not been documented 32 , and models have also identified Th2-skewing of the T cell response and lung eosinophilia with challenge after FI-RSV, raising the possibility that T cells contribute to vaccine-induced enhancement of RSV disease 31,33

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