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Rushing titration is one of the biggest reasons patients feel terrible on GLP-1 medications

Plus, a lowered desire for food also leads to consuming less calories

This timepoint was pre-specified to maximize the number observable while allowing sufficient duration of follow-up to evaluate the treatment effect reliably

Guo Z, et al

Trapp S, Brierley DI (2022) Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment

Whilst no direct causal link has been established in clinical trials, several physiological mechanisms related to the medication's effectsincluding metabolic changes from weight loss, altered digestion, and dietary modificationsmay theoretically explain these anecdotal observations