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This work was supported by the Major Program of the National Natural Science Foundation of China (No
The animals were kept in a controlled environment with stable temperature and humidity under a 12-hour light/dark cycle
FDA Guidance Documents
Both familial (fALS, 510% of cases) and sporadic (sALS) forms show similar clinical and pathological features, with overlapping cognitive and behavioral changes, particularly frontotemporal-like symptoms, as well as progressive bulbar and limb motor dysfunction
A: The difference comes down to manufacturing and testing