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Each drug has its own side effects, and when used together, these can overlap or intensify

This indicates that GSH is the main reductant responsible for maintaining the ER oxidoreductases in a reduced form, which is necessary for the reduction or isomerization of nonnative disulphide bonds

Temporally, CRC exhibits distinct metabolic evolution during progression from primary to metastatic disease [107]

Therefore, some studies have attempted to embed icariin-containing nanogels in poloxamer to develop an icariin nanogel self-assembled thermosensitive hydrogel system, which adheres to the nasal mucosa and prolongs drug release time, thereby improving its bioavailability