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Increased Rac1 activity may also exacerbate AD symptoms through free radicals in astrocytes as Rac1 was required for A-induced production of reactive oxygen species in these cells (Lee et al., 2002)

J Affect Disord 248:166174 Simpson TL, Rise P, Browne KC, Lehavot K, Kaysen D (2019) Clinical presentations, social functioning, and treatment receipt among individuals with comorbid life-time PTSD and alcohol use disorders versus drug use disorders: findings from NESARC-III