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2 GLP-1 receptors are expressed in brain regions involved in satiation, satiety, and reward, including the hypothalamus, brainstem, and mesolimbic pathways

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When reviewing the causality of adverse events, it is notable that the 1998 data on adverse events that were considered to be drug related (possibly, proba-bly or definitely) reveals that certain adverse events, most notably headache, occurred at higher incidence in subjects receiving placebo than in subjects receiv-ing active (Table 7.4)

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