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In addition to its role in maintaining a normal sleep-wake cycle, melatonin plays an important part in autonomic regulation, including blood pressure, pulse, and temperature, as well as immune response and glucose homeostasis

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These medications are GLP-1 receptor agonists (mimic a natural hormone regulating appetite and blood sugar)

In addition to the lean and ob/ob mice, the study included 3-KO mice and WT controls obtained from genetically verified breeding colonies