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In a later study, similar sensors were made to image Rac1 activity during sLTP in hippocampal neurons, and it was found that Rac1 was also required for the transient and sustained spine enlargement ( Rho GTPases in Synaptic Plasticity In addition to affecting spine properties, many studies have shown that Rho GTPases are potent regulators of synaptic transmission and plasticity (Figure 2)

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