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Imbalanced lipid homeostasis caused by membrane Klotho deficiency contributes to the acute kidney injury to chronic kidney disease transition

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In locus coeruleus neurons, cellular tolerance can be observed in brain slices prepared from animals treated with morphine for 3 days (Bailey et al., 2009a) and is reversed by administration of a PKC inhibitor

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Reframing this as successful adaptation rather than declining effectiveness helps maintain perspective

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