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We propose staged translation: initial human trials using systemic IV or intranasal delivery, reserving direct CNS approaches for refractory cases

Epidemiology 21 (6), 779785

E., Telem, D

Glutathione: Biochemistry, Mechanisms of Action and Biotechnological Implications (Microbiology Research Advances: Biochemisty Research Trends): 9781624174605: Medicine & Health Science Books @ Amazon.com

Inclusion criteria consisted of male and female participants without child bearing ability either due to menopause, documented hysterectomy, bilateral salpingectomy, bilateral oophorectomy, or bilateral tubal ligation, as well as age of at least 18 years, a body mass index of 30, or a body mass index of 27 with the presence of hypertension or dyslipidemia [1]

doi:10.1103/PhysRevA.66.013208