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Where it is sometimes considered, within a supervised plan, is in selected adults pursuing a comprehensive metabolic and regenerative protocol where AOD-9604 may serve as one minor lever among several, and where the patient understands the limits of the evidence

Science 343 , 204208 (2014)

Research suggests AOD-9604 may preserve existing muscle tissue during caloric restriction (a muscle-sparing effect), but this differs from actively building new muscle

That distinction matters because skin quality, recovery, and aging-related changes rarely depend on one factor alone