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In the context of IGFBP biology, IGF-1 LR3s 1000-fold reduced IGFBP affinity means it is not sequestered by IGFBP-3 (the major circulating IGF-1 carrier, ~75% of circulating IGF-1 is IGFBP-3 bound) or IGFBP-2 (the predominant IGFBP in muscle interstitium)

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However, it is difficult to determine whether CP therapy contributed to recovery as most studies to date were uncontrolled and many patients were also treated with other drugs, including antivirals and corticosteroids

Dinh QQ, Sinclair R (2007) Female pattern hair loss: current treatment concepts

Both reactions in the Rapoport-Luebering shunt are catalyzed by one multifunctional protein: 2,3-BPG mutase (BPGM) (EC 5.4.2.4).81,153 The mutase activity of this enzyme converts the glycolytic intermediate 1,3-BPG to 2,3-BPG