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Glutathione neutralizes harmful free radicals, supports detoxification by binding to toxins and heavy metals and recycles other antioxidants

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A clinical trial also reported a positive effect of Vitamin E in improving clinical symptoms and reducing oxidative stress conditions in patients with late-stage knee OA [165]

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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