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High glucose and advanced glycation end-product levels result in an obvious upregulation in the expression of intercellular adhesion molecules and vascular cell adhesion molecules, increased leukocyte adhesion to and migration across brain microvascular endothelial cell monolayers, and elevated BBB leakage in in vitro model with brain microvascular endothelial cells [79]

Some patients prefer a subtle improvement that maintains a graceful proportion, while others seek a fuller, more defined appearance

doi: 10.3389/fimmu.2021.742449 244 ZhuFTuHChenT

Genevive Beauchemin has more on the cost and the potential impacts.

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10.1093/oxfordjournals.aje.a008904 24 LarssonS