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(64) further clarified that only ER, and not ER, affected the expression of genes encoded by mitochondrial DNA in brain tissue, with ER activation serving as the primary mechanism for initiating the scavenging of lipid peroxides in brain mitochondria
By comparing these studies, it became clear that careful optimization of liposomal formulations (e.g., using high-purity phospholipids, proper size control) was required- a fact underscored by the delayed commercial success of liposomal nutraceuticals until the late 1990s
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