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Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo

In paired secretagogue models, concurrent GHRH and GHRP activation has been shown to produce synergistic growth hormone release, reflecting two functionally distinct pathways that converge at the level of pituitary output

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