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We therefore evaluated effects of a novel dual GLP-1R/GCGR agonist with higher potency for the GLP1-R, SAR425899, on energy metabolism such as EE and fat oxidation (13,14)

Through these combined mechanisms, GLP-1 RAs may contribute to remodeling of bile acid pools both directly and indirectly via microbiota interactions, thereby reinforcing gut-liver endocrine crosstalk and metabolic homeostasis (56, 87)

J Am Coll Cardiol (2013) 63(25 Pt B):302930

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Randomized, double-blind trial of triple therapy with saxagliptin add-on to dapagliflozin plus metformin in patients with type 2 diabetes

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